Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Nephrol Dial Transplant |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | diabetic nephropathy. pentose phosphate pathway. thiamine. thiamine deficiency. transketolase |
| Description | Pentose phosphate pathway (PPP) represents a potentially protective mechanism in hyperglycaemia due to shunting of glycolytic intermediates into PPP reactions. We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP enzymes transketolase (TKT), transaldolase and TKT-like might contribute to the progression of diabetic nephropathy (DN) and mortality of diabetics. |