Ototoxicita indukovaná cisplatinou - klinické sledování a stanovení individuální senzitivity
| Title in English | Ototoxicity Induced by Cisplatin - Clinical Observation and Determination of Individual Sensitivity |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Otorhinolaryngologie a foniatrie |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | ototoxicity; cisplatin; otoacoustic emissions; tone audiometry; sensory-neural hearing loss |
| Description | The clinical manifestation of ciplatin (CDDP) induced ototoxicity comprises unilateral or bilateral sensorial hearing los s (reversible or permanent) and tinnitus. The ototoxicity was shown to depend more on the individual sensitivity than on the total dose applied. The aim of the pilot study was to test (A) the effect of variable doses of CDDP and (B) efficiency of various diagnostic methods using three groups of patients. Otoacoustic emissions exhibited better predictive potential for final ototoxicity severity than classical tone audiometry. Presence of tinnitus did not predict degree of hearing loss. Based on the pilot study patients with the testicular and extragonadal germline tumors treated with CDDP were selected as an optimal study group for subsequent larger scale study. Apart from disease and treatment related parameters individual sensitivity will be assessed using genotyping of selected genetic markers in candidate genes related to oxidative/antioxidative balance. |