Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | International Journal of Infectious Diseases |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.ijid.2011.09.011 |
| Field | Oncology and hematology |
| Keywords | galaktomanan; BAL; invazivní plicní aspergilóza; hematologická malignita |
| Description | We evaluated the performance of a galactomannan (GM) assay in bronchoalveolar lavage (BAL) fluid compared to serum samples for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematological diseases. Results: Twenty-eight cases of IPA (11%) were diagnosed. The highest sensitivity (78.6%) with good specificity (98.6%) was obtained with a triple detection of GM in bronchial, alveolar, and serum samples. Neutropenia and antifungal therapy for only 24 h increased the sensitivity, while antifungal treatment for more than 2 days decreased assay performance.Conclusions: In contrast to recently published data, we found only moderate sensitivity, but high specificity and high positive predictive value of the detection of GM in BAL fluid. |