Neuroinfekce u onkologických pacientů.

Title in English Neuroinfections in oncologic patients


Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Description Involvement of the central and peripheral nervous system in children with neuroborreliosis occurs during the early disseminated infection, mostly parallel with erythema migrans. Clinical symptoms are not characteristic: intermittent headache, fatigue, myalgia, arthralgia, parestesia, subfebrilia, vomiting and minimal meningeal signs. Positive radiologic finding of intracranial lesion with suspicion for neoplastic process is rarely present in neuroborreliosis.During monitored period, 6 children with suspected oncologic diagnosis were admitted to the Department of Childrens Infectious Diseases, in 3 of them the diagnosis of neuroinfection was proven. Another 3 children were hospitalized with suspected neuroborreliosis. In the first patient with peripheral facial palsy and lymphocytic pleocytosis the therapy with ceftriaxone was started, nevertheless brain MRI scan showed the presence of large pontine glioma growing through the medulla oblongata. The next two patients underwent no CSF examination for papilloedema, in both brain tumors were diagnosed: ependymoma and astrocytoma.Tick-borne neuroinfections are infrequently observed in children with oncologic diagnosis. The procedure to the correct diagnosis is complicated due to suspicion for relapse of the underlying disease. Vice versa, despite of typical clinical symptoms, including tick-bite or erythema migrans, the differential diagnosis includes brain tumors in children.

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