Vztah genotypu apolipoproteinu E ke klinickému průběhu a následkům poranění mozku u dětí a mladistvých

Title in English Apolipoprotein E Genotype as an Independent Prognostic Factor for Clinical Outcome in Traumatic Brain Injury in Children and the Adolescent Population


Year of publication 2011
Type Article in Periodical
Magazine / Source Česká a slovenská neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Field Neurology, neurosurgery, neurosciences
Keywords apolipoprotein E; cerebral injury; Glasgow Coma Scale; Extended Glasgow Outcome Scale; paediatric population; adolescent population
Description Aims: In the light of available published data, the authors considered the prospects of worse clinical outcome after brain injury more likely for patients possessing the 4 apolipoprotein E allele in both the paediatric and adolescent populations. The aim was to examine this hypothesis by means of a cohort of paediatric and adolescent patients with cerebral injuries. Materials and method: The presence of apolipoprotein E genotype was investigated in a group of 82 paediatric and adolescent patients who had suffered traumatic brain injury. The severity of trauma was assessed by the Glasgow coma scale. Clinical outcome after one year was assessed by the extended Glasgow outcome scale. Severity of injury was compared with clinical outcome after one year with respect to apolipoprotein E genotype and evaluated statistically using the Wilcoxon nonparametric test, Students t-test and Fischer tests. Results: Analysis of the data obtained confirmed a relationship between the presence of apolipoprotein E allele and worse clinical course after brain injury in children and adolescents. Children and adolescent patients possessing the apolipoprotein E allele have a higher risk of unfavourable clinical outcome after serious brain injury, compared to a significantly better outcome in patients with other apolipoprotein E alleles. Conclusions: Apolipoprotein E genotype is an independent prognostic factor for clinical outcome in traumatic brain injury in children and the adolescent population.

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