Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

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Authors	DVORAKOVA D. KREJČÍ Pavel MAYER Jiří FAJKUS Jiří HAMPL Aleš DVOŘÁK Petr
Year of publication	2001
Type	Article in Periodical
Magazine / Source	British journal of haematology
MU Faculty or unit	Faculty of Science
Citation
Doi	http://dx.doi.org/10.1046/j.1365-2141.2001.02829.x
Field	Physiology
Keywords	fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis
Description	Fibroblast growth factor receptors (FGFR1-4) are implicated in various cellular events, including cell growth and transformation. Here, we showed that patients suffering from chronic myeloid leukaemia (CML) express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. However, FGFR3 expression became upregulated again in those patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia. Our findings suggest that. in CML, the changing levels of FGFR3 transcripts in WBCs map have prognostic significance.