Apolipoprotein E Polymorphism Is Associated with Both Number of Diseased Vessels and Extent of Coronary Artery Disease in Czech Patients with CAD



Year of publication 2012
Type Article in Periodical
Magazine / Source Biomedical Papers
MU Faculty or unit

Faculty of Medicine

Doi http://dx.doi.org/10.5507/bp.2012.051
Field Cardiovascular diseases incl. cardiosurgery
Keywords coronary artery disease; apolipoprotein E; coronary angiography; atherosclerosis
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Description Aims. The impact of ApoE polymorphism on angiographic parameters was assessed in patients referred for coronary angiography. Methods. Elective coronary angiography was performed in 671 subjects (525 men, 146 women, mean age 60+/-10 years) with symptoms of ischemic heart disease. The patients were divided into: no CAD group (smooth coronary vessels, n=83), one-vessel (n=155), two-vessel (n=170) and three-vessel disease (n=196). Patients with stenoses 0-50% were excluded. Within patients with CAD, we evaluated overall extent of CAD measured by the number of stenotic segments according to AHA (1 segment vs. 2–3 vs. more than 4), and the severity of the most serious stenosis (in percent). ApoE genotype was determined using real-time PCR. Results. The frequency of epsilon2/epsilon3 genotype (n=56) was lower in the three-vessel disease group compared to one-vessel disease (OR=0.25, P=0.0019), two-vessel disease (OR=0.31, P=0.0114) or no CAD group (OR=0.24, P=0.0057). Frequency of epsilon2/epsilon3 decreased with the number of affected segments (1 vs. more than 4: OR=0.35, P=0.0143). The epsilon3/epsilon4 +epsilon4/epsilon4 genotypes (n=123) were more frequent in CAD patients altogether compared with no CAD group (OR=2.30, P=0.019), while no impact of the epsilon4 allele on angiographic parameters within the CAD patients was detected. In epsilon2/epsilon3 carriers with CAD, lower LDL-cholesterol, total cholesterol and lower use of lipid-lowering drugs were observed. Conclusions. The results show predominantly focal form of CAD in patients with epsilon2/epsilon3 genotype. Lower LDL-cholesterol and total cholesterol may play the key role, although other contributing factors are discussed.
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