Studium vybraných transkribovaných ultrakonzervovaných regionů (T-UCR) u pacientů s kolorektálním karcinomem

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Title in English Study of selected ultraconserved regions (T-UCR) in colorectal cancer patients.
Authors

ŠÁNA Jiří HANKEOVÁ Simona SVOBODA Marek NĚMEČEK Radim VYZULA Rostislav SLABÝ Ondřej

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Description The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequences longer than 200 bp, which are absolutely conserved between orthologous regions of human, rat and mouse genomes, and are actively transcribed. It has recently been proven in cancer systems that differentially expressed T-UCRs could alter the functional characteristics of malignant cells. Genome-wide profiling revealed that T-UCRs have distinct signatures in human leukemia and carcinoma.
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