Advances in patch clamp technique: towards higher quality and quantity



Year of publication 2012
Type Article in Periodical
Magazine / Source General physiology and biophysics
MU Faculty or unit

Faculty of Medicine

Field Physiology
Keywords Action potential clamp; Dynamic clamp; Cell-type transforming clamp; High-resolution scanning patch clamp; Automated patch clamp
Description The patch clamp technique, developed in late 1970s, started a new period of experimental cardiac electrophysiology enabling measurement of ionic currents on isolated cardiomyocytes down to the level of single channels. Since that time, the technique has been substantially improved by development of several upgraded modifications providing so far unavailable data (e.g. action potential clamp, dynamic clamp, high-resolution scanning patch clamp), or facilitating the patch clamp technique by increasing its efficiency (planar patch clamp, automated patch clamp). The current review summarizes the leading new patch clamp based techniques used in cardiac cellular electrophysiology, their principles and prominent related papers.
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