Relevance of CYP2D6 variability in first-episode schizophrenia patients treated with risperidone

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Authors

BARTEČEK Richard JUŘICA Jan ZRUSTOVA Jana KAŠPÁREK Tomáš PINDUROVÁ Eva ŽOURKOVÁ Alexandra

Year of publication 2012
Type Article in Periodical
Magazine / Source Neuroendocrinology Letters
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.ncbi.nlm.nih.gov/pubmed/22592207
Field Neurology, neurosurgery, neurosciences
Keywords Cytochrome P-450; CYP2D6; pharmacogenetics; CYP2D6 analysis; schizophrenia; risperidone
Description OBJECTIVE: The objective of this prospective, naturalistic study, conducted in first-episode psychosis patients from a Central-European population, was to assess the utility of Cytochrome P-450 2D6 (CYP2D6) genotype testing under normal clinical setting. METHODS: A total of 35 patients diagnosed for the first time with schizophrenia or acute schizophrenia-like psychotic disorder and treated with risperidone were enrolled in the study. These patients underwent sequentiation of the CYP2D6 gene and evaluations of symptoms and severity of adverse effects using the PANSS and UKU scales, respectively. Doses of antipsychotics and other co-medication were monitored as well. In statistical analysis, Fisher's exact test was used to compare ratios and the Wilcoxon rank-sum test was used in the comparison of continual variables. RESULTS: PM patients showed a significantly lower reduction in psychotic symptoms and a greater severity of psychotic symptoms following risperidone treatment and higher doses of antipsychotics not metabolized by CYP2D6, which were used as co-medication. CONCLUSIONS: Based on these results, patients with the PM genotype experiencing first-episode schizophrenia don't appear to be optimal recipients of risperidone treatment. However, as the main limitation of this study was the relatively small sample-size, replication with a larger scale study is needed to confirm these findings.
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