Význam mikroprostředí kostní dřeně v patogenezi mnohočetného myelomu
| Title in English | Implication of Bone Marrow Microenvironment in Pathogenesis of Multiple Myeloma |
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| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | Multiple myeloma; bone marrow microenvironment; pathogenesis; treatment |
| Attached files | |
| Description | Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance. |
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