Human adult Treg microRNA signature: the role of microRNA-31 in FOXP3 regulation.
| Authors | |
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| Year of publication | 2011 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | MicroRNA are small non-coding RNA molecules that have a potential to regulate the expression of many genes. Regulatory T cells (Tregs) are characterized by expression of the fork head-winged helix transcription factor FOXP3. Tregs are specialized lymphocytes with immunomodulatory effects preventing from development of autoimmune disorders. Studies on transgenic mouse with conditional dicer knockout Treg revealed that Treg cell-specific microRNA ablation results in the loss of suppressor function and development of fatal systemic autoimmune disease in vivo. Therefore, we assume that the functional defect of Tregs in patients with an autoimmune disease can be caused by different microRNAs expression in these cells. Thus, we performed the broad spectrum microRNA profiling in a population of Tregs separated from peripheral blood of 11 donors and compared microRNA expression profiles of Tregs with conventional T cells. |