Internal Flames: Metal(loid) Exposure Linked to Alteration of the Lipid Profile in Czech Male Firefighters (CELSPAC-FIREexpo Study)

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Authors

PÁLEŠOVÁ Nina ŘIHÁČKOVÁ Katarína KUTA Jan PINDUR Aleš ŠEBEJOVÁ Ludmila ČUPR Pavel

Year of publication 2024
Type Article in Periodical
Magazine / Source ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
MU Faculty or unit

Faculty of Science

Citation
Web https://pubs.acs.org/doi/10.1021/acs.estlett.4c00272
Doi http://dx.doi.org/10.1021/acs.estlett.4c00272
Keywords firefighters; occupational exposure; metals; cholesterol; cardiovascular disease; mixture analysis
Attached files
Description Increased wildfire activity increases the demands on fire rescue services and firefighters’ contact with harmful chemicals. This study aimed to determine firefighters’ exposure to toxic metal(loid)s and its association with the lipid profile. CELSPAC-FIREexpo study participants (including 110 firefighters) provided urine and blood samples to quantify urinary levels of metal(loid)s (arsenic, cadmium (Cd), mercury, and lead (Pb)), and serum lipid biomarkers (cholesterol (CHOL), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides (TG)). The associations were investigated by using multiple linear regression and Bayesian weighted quantile sum (BWQS) regression. Higher levels of Pb were observed in firefighters. Pb was positively associated with CHOL and TG. Cd was negatively associated with HDL. In the BWQS model, the mixture of metal(loid)s was associated positively with CHOL (ß = 14.75, 95% CrI = 2.45–29.08), LDL (ß = 15.14, 95% CrI = 3.39–29.35), and TG (ß = 14.79, 95% CrI = 0.73–30.42), while negatively with HDL (ß = -14.96, 95% CrI = -25.78 to -1.8). Pb emerged as a key component in a metal(loid) mixture. The results suggest that higher exposure to lead and the mixture of metal(loid)s is associated with the alteration of the lipid profile, which can result in an unfavorable cardiometabolic profile, especially in occupationally exposed firefighters.
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