Patient-Friendly LC–MS Therapeutic Drug Monitoring in Alternative Matrices
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| Year of publication | 2025 |
| Type | Appeared in Conference without Proceedings |
| Citation | |
| Description | Therapeutic Drug Monitoring (TDM) is crucial for optimizing antiseizure medication (ASM) therapy in epilepsy management. However, patients often show considerable variability in ASM concentration due to differing pharmacokinetics. Conventional TDM is based on venous blood sampling, which can be invasive and less practical in outpatient or home settings. This work presents a developed LC–MS method for simultaneous measurement of seven ASMs in three alternative matrices: saliva, dried saliva spots (DSS) and dried blood spots (DBS). These matrices offer clear advantages for clinical use: saliva sampling is completely non-invasive, DBS requires only a small finger prick, and both simplify sample handling, storage and transport. |
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