TARGETING ENDOPLASMIC RETICULUM STRESS TO REPROGRAM THE TUMOR IMMUNE MICROENVIRONMENT IN OVARIAN CANCER
| Authors | |
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| Year of publication | 2026 |
| Type | Appeared in Conference without Proceedings |
| Citation | |
| Description | This study explores the pivotal role of Endoplasmic Reticulum Stress (ERS) modulation in reshaping the TIME of OC. By utilizing in vitro models and a syngeneic in vivo murine model, we evaluated how ERS modulation can influence tumor progression and immune response. Our results demonstrate that ERS modulation reconfigures the TIME to enhance the antitumor activity of immune cells, thereby improving immunotherapy efficacy. By attenuating systemic immunosuppression, ERS-targeted therapies could overcome the "cold" immune nature of many cancers. This study provides a strong mechanistic rationale for combining ERS modulators with immunotherapy to enhance therapeutic outcomes in resistant OC phenotypes. |