Cilia and Centrosome Biology

The research team of cell biologists is tackling the structure and function of primary cilia and centrosomes in human cells for living. Primary cilia are antenna–like organelles present on the cell surface, templated by the older ("mother") centriole in non-dividing cells. In dividing cells, centrioles form the centrosome, a mitotic spindle organiser that facilitates cell division. Correctly tuned signalling orchestrated by primary cilia (e.g. Hedgehog pathway) is essential both for embryo development and adult tissue homeostasis. Deregulation of either cilia or centrosome biology often leads to disease. Successful treatment of such diseases calls for a better understanding of their origin. The research group has expertise in molecular and cell biology approaches, including proteomics, gene editing, stem cells, super-resolution microscopy, live cell imaging microscopy, and biochemistry.