Genomics of Immune Cells

The team builds on its recent experience and works on projects focused on understanding the impact of inherited and acquired genomic variants, primarily in cancer cells, complemented with the assessment of gene expression, epigenetic modification and chromatin accessibility. Due to the genomic variants complexity,  it is necessary to employ a multi-faceted analysis including several genomic, cytogenomic and computational methods to reveal their native structure and consequences on genome expression. Part of the research is devoted to analysing chromatin interactions and interacting domains, such as topologically associated domains (TADs). Finally, tumour progression is typically associated with intra-tumoral heterogeneity, which is studied using technologies with single-cell resolution and mathematical models. The team also develops user-friendly tools for their evaluation. Similar approaches are used for sharing the most interesting findings with the scientific community via interactive websites.