Monophasic synovial sarcoma of the lower extremity at 20 weeks of pregnancy: a case report and review of the literature

Authors

BIELIKOVA P. PILKA R. HUML K. MELICHAR B. SVEBISOVA H. JANKOVA J. PRASIL V. ZAMBO I. JANÍČEK Pavel

Type Article in Periodical
Magazine / Source CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.12891/ceog4877.2019
Doi http://dx.doi.org/10.12891/ceog4877.2019
Keywords Synovial sarcoma; Malignancy; Pregnancy; Limb-sparing surgery
Description Introduction: The incidence of malignancy in pregnancy is reported to range approximately between 0.02% and 1%. Synovial sarcoma (SS) is a rare aggressive mesenchymal tumor for which there are no treatment guidelines during pregnancy. Case Report: The authors report a 23-year-old primigravida presenting. at 20+0 weeks of pregnancy. with a growing painful mass in the left thigh. The diagnosis of monophasic SS grade 3 was confirmed by the presence of SYT gene fusion. On MRI scan there was a heterogeneous localized mass of size 75 x115 x103 mm, but there was no evidence of distant metastases. Limb-sparing surgery with clear-surgical margins was performed at 26+3 weeks of pregnancy. Adjuvant chemotherapy with two cycles of doxorubicin was followed by delivery of normal child by caesarean section at 36+3 weeks of pregnancy. Adjuvant radiotherapy of total dose of 66 Gray to the site of the resection had been administered followed by two cycles of doxorubicin. Conclusion: The patient is free of recurrence six months after the completion of the treatment.