Czech Infrastructure for Integrative Structural Biology (CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 271
2023
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Nature of NMR Shifts in Paramagnetic Octahedral Ru(III) Complexes with Axial Pyridine-Based Ligands
Inorganic Chemistry, rok: 2023, ročník: 62, vydání: 8, DOI
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Pseudomonas petrae sp. nov. isolated from regolith samples in Antarctica
Systematic and Applied Microbiology, rok: 2023, ročník: 46, vydání: 4, DOI
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Staphylococcus aureus Prophage-Encoded Protein Causes Abortive Infection and Provides Population Immunity against Kayviruses
mBio, rok: 2023, ročník: 14, vydání: 2, DOI
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Targeting undruggable oncoproteins c-Myc and N-Myc by the 9aaTADs
Rok: 2023, druh: Další prezentace na konferencích
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The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD
The Biochemical journal, rok: 2023, DOI
2022
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14-3-3 protein isoforms: mutual dimerization propensities screening kit
Rok: 2022, druh: Konferenční abstrakty
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A GP1BA Variant in a Czech Family with Monoallelic Bernard-Soulier Syndrome
International Journal of Molecular Sciences, rok: 2022, ročník: 23, vydání: 2, DOI
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A large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Proteomics, rok: 2022, ročník: 22, vydání: 7, DOI
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A new fibrillization mechanism of β-lactoglobulin in glycine solutions
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, rok: 2022, ročník: 216, vydání: SEP, DOI
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A release of Ti-ions from nanostructured titanium oxide surfaces
Surfaces and Interfaces, rok: 2022, ročník: 29, vydání: April 2022, DOI