Czech Infrastructure for Integrative Structural Biology (CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 271
2022
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A switch from alpha-helical to beta-strand conformation during co-translational protein folding
EMBO Journal, rok: 2022, ročník: 41, vydání: 4, DOI
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Adamantane-Substituted Purine Nucleosides: Synthesis, Host-Guest Complexes with beta-Cyclodextrin and Biological Activity
International Journal of Molecular Sciences, rok: 2022, ročník: 23, vydání: 23, DOI
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Airborne Preparation of Small Gold Nanoparticles Dispersed on Mesoporous Silica for the Catalytic Oxidation of Glycerol to Dihydroxyacetone
ACS Applied Nano Materials, rok: 2022, ročník: 5, vydání: 12, DOI
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Aminophylline Induces Two Types of Arrhythmic Events in Human Pluripotent Stem Cell–Derived Cardiomyocytes
Frontiers in Pharmacology, rok: 2022, ročník: 12, vydání: January, DOI
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Asymmetric Organocatalyzed Friedel-Crafts Reaction of Trihaloacetaldehydes and Phenols
Advanced Synthesis and Catalysis, rok: 2022, ročník: 364, vydání: 13, DOI
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Atomic Force Spectroscopy is a promising tool to study contractile properties of cardiac cells
Micron, rok: 2022, ročník: 155, vydání: APR, DOI
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Bile Acids Transporters of Enterohepatic Circulation for Targeted Drug Delivery
Molecules, rok: 2022, ročník: 27, vydání: 9, DOI
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Biomolecular Complexation on the "Wrong Side": A Case Study of the Influence of Salts and Sugars on the Interactions between Bovine Serum Albumin and Sodium Polystyrene Sulfonate
Biomacromolecules, rok: 2022, ročník: 23, vydání: 10, DOI
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Biophysical characterization of extracellular carbonic anhydrase IX
Rok: 2022, druh: Konferenční abstrakty
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Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction
Biophysical Journal, rok: 2022, ročník: 121, vydání: 9, DOI