Czech Infrastructure for Integrative Structural Biology (CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
-
Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 271
2022
-
Characterization of insulin crystalline form in isolated beta-cell secretory granules
Open Biology, rok: 2022, ročník: 12, vydání: 12, DOI
-
Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer Cells
Molecular & Cellular Proteomics, rok: 2022, ročník: 21, vydání: 2, DOI
-
Characterizing toxicity pathways of fluoxetine to predict adverse outcomes in adult fathead minnows (Pimephales promelas)
SCIENCE OF THE TOTAL ENVIRONMENT, rok: 2022, ročník: 817, vydání: APR, DOI
-
Infrared Laser Desorption of Intact Nanoparticles for Digital Tissue Imaging
Analytical Chemistry, rok: 2022, ročník: 94, vydání: 51, DOI
-
Instruct Council Meeting
Rok: 2022, druh: Popularizační texty
-
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
Frontiers in Cell and Developmental Biology, rok: 2022, ročník: 10, vydání: February 2022, DOI
-
Magainin 2 and PGLa in Bacterial Membrane Mimics III: Membrane Fusion and Disruption.
Biophysical Journal, rok: 2022, ročník: 121, vydání: 5, DOI
-
Measurement of Liver Stiffness using Atomic Force Microscopy Coupled with Polarization Microscopy
Journal of Visualized Experiments, rok: 2022, ročník: 2022, vydání: 185, DOI
-
Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel
Rok: 2022, druh: Konferenční abstrakty
-
Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel
Folia Mendeliana : supplementum ad Acta Musei Moraviae, rok: 2022, ročník: 58, vydání: 1