Informace o projektu
Národní centrum lékařské genomiky
(NCLG)
- Kód projektu
- LM2018132
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
-
Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
-
Univerzita Karlova v Praze
- Odpovědná osoba prof. Ing. Stanislav Kmoch, CSc.
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 73
2022
-
Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes
BMC Cancer, rok: 2022, ročník: 22, vydání: 1, DOI
-
Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture
Nature Scientific Reports, rok: 2022, ročník: 12, vydání: 1, DOI
-
Global Transcriptomic Analysis of Bacteriophage-Host Interactions between a Kayvirus Therapeutic Phage and Staphylococcus aureus
Microbiology Spectrum, rok: 2022, ročník: 10, vydání: 3, DOI
-
Gregor Johann Mendel. Cesty ke genomu zakladatele genetiky | Begründer der Genetik – die Wege zu seinem Genom | Ways to the genome of the founder of genetics
Rok: 2022, vydání: Vyd. 1., počet stran: 197 s.
-
Gut-content analysis in four species, combined with comparative analysis of trophic traits, suggests an araneophagous habit for the entire family Palpimanidae (Araneae)
Organisms Diversity & Evolution, rok: 2022, ročník: 22, vydání: 1, DOI
-
HLA-E and HLA-F Are Overexpressed in Glioblastoma and HLA-E Increased After Exposure to Ionizing Radiation
CANCER GENOMICS & PROTEOMICS, rok: 2022, ročník: 19, vydání: 2, DOI
-
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis
Molecular Cancer, rok: 2022, ročník: 21, vydání: 1, DOI
-
LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro
JOURNAL OF CLINICAL LABORATORY ANALYSIS, rok: 2022, ročník: 36, vydání: 6, DOI
-
Long read targeted sequencing enables genomic analysis of translocation hotspots in lymphoproliferative diseases
Rok: 2022, druh: Konferenční abstrakty
-
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
Frontiers in Cell and Developmental Biology, rok: 2022, ročník: 10, vydání: February 2022, DOI