Spatial transcriptomics of mammary gland organoids

Kód projektu
Období řešení
10/2020 - 9/2021
Investor / Programový rámec / typ projektu
Masarykova univerzita
Fakulta / Pracoviště MU
Lékařská fakulta

Mammary gland (MG) is a highly dynamic organ that undergoes massive changes in its structure and function during female’s reproductive life. These changes are tightly regulated because any aberrations can lead to organ dysfunction or disease, including breast cancer. Under overall systemic control by reproductive hormones, MG development is determined by location-specific interactions within the mammary microenvironment. Therefore, to decipher new mechanisms that regulate MG development and cancer, unbiased approaches that include spatial information are required. In this project, we aim to develop a new protocol for spatial transcriptomics on MG organoids as a powerful tool for uncovering mechanisms that regulate breast development and cancer.

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