Immunomonitoring of patients treated with personalized dendriticcell-based vaccine

Název česky Imunomonitoring pacientů lečených autologní protinádorovou vakcínou z dendritických buněk
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FĚDOROVÁ Lenka ZDRAŽILOVÁ DUBSKÁ Lenka PILÁTOVÁ Kateřina MÚDRY Peter MAZÁNEK Pavel PAVELKA Zdeněk HLAVÁČKOVÁ Eva DEMLOVÁ Regina FLAJŠAROVÁ Lucie ŠTĚRBA Jaroslav VALÍK Dalibor

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Časopis / Zdroj Annals of Oncology
Citace
Doi http://dx.doi.org/10.1093/annonc/mdx711
Klíčová slova immunomonitoring, dendritic cell-based, personalized
Popis We manufacture fully personalized monocytederived dendritic cell-based vaccines (DC-based vaccines) that are evaluated in investigator- initiated clinical trial “Combined antitumor therapy with ex vivo manipulated dendritic cells producing interleukin-12 in children, adolescents and young adults with progressive, recurrent or primarily metastatic high-risk tumors”. Detailed immunomonitoring of peripheral blood leucocytes subsets at the baseline and during vaccination is performed and includes routine examined peripheral blood parameters, monocyte subsets, MDSC, specific lymphocyte subsets including Tregs, effector Tcells, NKT-like cells.
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