Time course of urinary neopterin in a non-Hodgkin's lymphoma patient during chemotherapy and radiotherapy


TOMANDL Josef PALYZA Vladimír TALLOVÁ Jaroslava DRBAL Josef

Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Experimental & Clinical Cancer Research
Fakulta / Pracoviště MU

Lékařská fakulta

www http://crs.ifo.it
Obor Onkologie a hematologie
Klíčová slova neopterin - non-Hodgkin's lymphoma
Popis The objective of this study was to follow urinary neopterin in a patient affected by non-Hodgkin's lymphoma in Stage IV (centrocyto-centroblastic type)during the three months treatment from the onset of the disease. He was treated with combined chemotherapy and local radiotherapy. Neopterin was measured by high performance liquid chromatography in the first morning urine specimens. Over 70 % of the received values were higher than the upper limit of normal excretion of healthy subjects. Longitudinal analysis showed a relatively big variance of urinary neopterin with a tendency of decrease during the treatment. The significant decrease of urinary neopterin was observed till after a radiotherapy period following the chemotherapy period.