Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Autoři	JANÍKOVÁ Andrea MARECKOVA Andrea BAUMEISTEROVA A. KREJČÍ Marta ŠUPÍKOVÁ Jana ŠÁLEK David HORKÝ Ondřej TICHÝ Boris HANKE Ivo POSPÍŠILOVÁ Šárka MOULIS Mojmír MAYER Jiří
Rok publikování	2014
Druh	Článek v odborném periodiku
Časopis / Zdroj	LEUKEMIA & LYMPHOMA
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.3109/10428194.2013.858150
Obor	Onkologie a hematologie
Klíčová slova	BONE-MARROW-TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; CLONAL IMMUNOGLOBULIN; RELAPSE; GENE
Přiložené soubory	Transmission_of_t_11_14_skeny_evidencnich_listu.pdf
Popis	Mantle cell lymphoma (MCL) is considered, with some exceptions, to be one of the most aggressive lymphomas, with relatively short median survival [1]. Th e biological hallmark of MCL is t(11;14)(q13;q32) resulting in cyclin D1 overexpression, which is not usually expressed in normal B cells [2]. Although the initial oncogenic translocation is acquired at the pre-B stage during the V(D)J recombination in the bone marrow [3], MCL is composed of mature B cells that grow in the mantle zone of lymphatic follicles and express the corresponding phenotype. To date, the oncogenic steps from the early event to the development of MCL have not been well documented. Rare cases of donor-derived malignancies can provide better insights into the biology and growth of different tumors under real conditions.