Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis
| Autoři | |
|---|---|
| Rok publikování | 2014 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | European Journal of Pharmaceutics and Biopharmaceutics |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.sciencedirect.com/science/article/pii/S0939641113003846 |
| Doi | http://dx.doi.org/10.1016/j.ejpb.2013.12.002 |
| Obor | ORL, oftalmologie, stomatologie |
| Klíčová slova | Mucoadhesive buccal films; Solvent casting method; Method of impregnation; Carmellose; Non-woven textile; Backing layer; In vitro testing; In vivo evaluation; Multivariate data analysis; Residence time |
| Popis | Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects of in vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer. The addition of polyethylene oxide prolonged the in vivo film residence time (from 53.24±5.38-74.18±5.13min to 71.05±3.15-98.12±1.75min), and even more when combined with an ethylcellulose backing layer (98.12±1.75min) and also improved the film's appearance. Tested non-woven textile shortened the in vivo film residence time (from 74.18±5.13-98.12±1.75min to 53.24±5.38-81.00±8.47min) and generally worsened the film's appearance. Mucoadhesive buccal films with a hydrophobic backing layer were associated with increased frequency of adverse effects. |