Subthalamic nucleus involvement in executive functions with increased cognitive load: a subthalamic nucleus and anterior cingulate cortex depth recording study

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Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

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AULICKÁ Štefánia JURÁK Pavel CHLÁDEK Jan DANIEL Pavel HALÁMEK Josef BALÁŽ Marek BOČKOVÁ Martina CHRASTINA Jan REKTOR Ivan

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Neural Transmission
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://link.springer.com/article/10.1007%2Fs00702-014-1191-5
Doi http://dx.doi.org/10.1007/s00702-014-1191-5
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova ERD/S; Anterior cingulate cortex; Subthalamic nucleus; Flanker test; Executive functions
Přiložené soubory
Popis We studied the appearance of broadband oscillatory changes (ranging 2–45 Hz) induced by a cognitive task with two levels of complexity. The event-related de/synchronizations (ERD/S) in the subthalamic nucleus (STN) and in the anterior cingulate cortex (ACC) were evaluated in an executive function test. Four epilepsy surgery candidates with intracerebral electrodes implanted in the ACC and three Parkinson’s disease patients with externalized deep brain stimulation electrodes implanted in the STN participated in the study. A Flanker test (FT) with visual stimuli (arrows) was performed. Subjects reacted to four types of stimuli presented on the monitor by pushing the right or left button: congruent arrows to the right or left side (simple task) and incongruent arrows to the right or left side (more difficult complex task). We explored the activation of STN and the activation of the ACC while processing the FT. Both conditions, i.e. congruent and incongruent, induced oscillatory changes in the ACC and also STN with significantly higher activation during incongruent trial. At variance with the ACC, in the STN not only the ERD beta but also the ERD alpha activity was significantly more activated by the incongruent condition. In line with our earlier studies, the STN appears to be involved in activities linked with increased cognitive load. The specificity and complexity of task-related activation of the STN might indicate the involvement of the STN in processes controlling human behaviour, e.g. in the selection and inhibition of competing alternatives.
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