Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels

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BÉBAROVÁ Markéta MATEJOVIČ Peter HOŠEK Jan ŠIMURDOVÁ Milena ŠIMURDA Jiří

Rok publikování 2014
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis This is the first study demonstrating an effect of ethanol on the atrial IK1. The ethanol effect was apparent in a clinically relevant concentration and partly differed in rat atrial myocytes and in the expressed human Kir2.3 channels. The decline of IK1-inhibition during application of ethanol observed in rat atrial cells along with the following increase of IK1 in a part of these cells may be caused by an unknown mechanism which is not present in the human Kir2.3 channels expressed in CHO cells. Our experimental data suggest that ethanol-induced changes of the atrial IK1 might participate in the reported alterations of atrial electrophysiology under alcohol consumption.
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