Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency
Autoři | |
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Rok publikování | 2016 |
Druh | Článek v odborném periodiku |
Fakulta / Pracoviště MU | |
Citace | |
Doi | http://dx.doi.org/10.1038/ng.3675 |
Obor | Epidemiologie, infekční nemoci a klinická imunologie |
Klíčová slova | Autoimmune diseases; Genome-wide association studies; Immunological deficiency syndromes |
Přiložené soubory | |
Popis | Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Europeans. Our genome-wide association study (GWAS) meta-analysis of 1,635 patients with IgAD and 4,852 controls identified four new significant (P < 5 × 10-8) loci and association with a rare IFIH1 variant (p.Ile923Val). |
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