No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation

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Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Global Dermatology
Fakulta / Pracoviště MU

Lékařská fakulta

Obor Dermatovenerologie
Klíčová slova HSPB7; SNP; rs1048261; miRNA; microRNA; psoriasis; cardiovascular disease; comorbidity
Přiložené soubory
Popis Previous studies have shown an increased risk of cardiovascular diseases in patients with psoriasis. It has also been known that abnormal levels of microRNA (miRNA) contribute to the pathogenesis of psoriasis and its comorbidities. Moreover, single nucleotide polymorphisms(SNPs) within miRNA genes or 3’UTR of the miRNA target genes can alter gene expression and thus contribute to the pathogenesis of the disease. Assess SNP rs1048261 within the 3’UTR of HSPB7 in a large cohort (n=558) of psoriatic patients of Central European Caucasian origin and evaluate its possible role in the increased risk of cardiovascular disease (CVD) in psoriasis patients. This study included 558 patients diagnosed with psoriasis; 30% of the patients had a personal history of CVD. In silico analysis was used to determine a candidate SNP which is associated with a potential impairment of miRNA-mediated translational regulation. The chosen SNP rs1048261 was genotyped using PCR-RFLP and all statistical analyses were performed using statistical software R. Possible interactions of the genotype and personal history of CVD were tested, but no significant association was found. Subsequently, the linical subtypes of psoriasis (plaque psoriasis, pustular psoriasis and guttate psoriasis) as well as age at psoriasis onset were analyzed to associate the genotype with CVD, but neither association was found to be statistically significant. Finally, the logistic regression model was created to test any possible associations with the personal history of CVD, but all results were inconclusive. Although our study did not provide any significant association of the SNP rs1048261 with cardiovascular morbidity, we suggest investigating this polymorphism in a cohort of patients with properly diagnosed cardiovascular diseases independently of psoriasis. Also, the validation of miRNA-mRNA interaction and SNP rs1048261 involvement needs to be studied.
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