First report of Sneathia sanguinegens together with Mycoplasma hominis in postpartum prosthetic valve infective endocarditis: a case report

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Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

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KOTÁSKOVÁ Iva NĚMEC Petr VANĚRKOVÁ Martina MALIŠOVÁ Barbora TEJKALOVÁ Renata ORBAN Marek ŽAMPACHOVÁ Víta FREIBERGER Tomáš

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj BMC INFECTIOUS DISEASES
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2654-8
Doi http://dx.doi.org/10.1186/s12879-017-2654-8
Obor Epidemiologie, infekční nemoci a klinická imunologie
Klíčová slova Infective endocarditis; Postpartum endocarditis; Sneathia; Mycoplasma; Polymicrobial infections
Popis Background: The presence of more than one bacterial agent is relatively rare in infective endocarditis, although more common in prosthetic cases. Molecular diagnosis from a removed heart tissue is considered a quick and effective way to diagnose fastidious or intracellular agents. Case presentation: Here we describe the case of postpartum polymicrobial prosthetic valve endocarditis in a young woman. Sneathia sanguinegens and Mycoplasma hominis were simultaneously detected from the heart valve sample using broad range 16S rRNA polymerase chain reaction (PCR) followed by sequencing while culture remained negative. Results were confirmed by independent PCR combined with denaturing gradient gel electrophoresis. Before the final agent identification, the highly non-compliant patient left from the hospital against medical advice on empirical intravenous treatment with aminopenicillins, clavulanate and gentamicin switched to oral amoxycillin and clavulanate. Four months after surgery, no signs of inflammation were present despite new regurgitation and valve leaflet flail was detected. However, after another 5 months the patient died from sepsis and recurrent infective endocarditis of unclarified etiology. Conclusions: Mycoplasma hominis is a rare causative agent of infective endocarditis. To the best of our knowledge, presented case is the first report of Sneathia sanguinegens detected in this condition. Molecular techniques were shown to be useful even in polymicrobial infective endocarditis samples.
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