Minimally invasive mitral valve repair for functional mitral regurgitation in severe heart failure: MitraClip versus minimally invasive surgical approach
| Autoři | |
|---|---|
| Rok publikování | 2016 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Interactive CardioVascular and Thoracic Surgery |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://dx.doi.org/10.1093/icvts/ivw215 |
| Doi | http://dx.doi.org/10.1093/icvts/ivw215 |
| Obor | Kardiovaskulární nemoci včetně kardiochirurgie |
| Klíčová slova | MitraClip; Mitral valve repair; Functional mitral regurgitation; Outcome |
| Popis | To compare the outcomes of MitraClip versus minimally invasive surgical mitral valve repair in high-risk patients with significant functional mitral regurgitation (FMR) and severe heart failure in a centre having pilot versus extensive experience with the MitraClip and the minimally invasive surgical approach, respectively. The MitraClip group consisted of 24 high-surgical-risk patients [age 75 +/- 9 years, 75% males, NYHA III/IV 88%, left ventricular (LV) ejection fraction 31 +/- 9%, EuroSCORE II 18 +/- 14%], while the surgical group consisted of 48 patients matched for age, NYHA class and LV ejection fraction. Patients undergoing MitraClip versus those undergoing surgical repair showed higher prevalence of ischaemic LV dysfunction and larger LV end-diastolic diameter (both P < 0.05). Both the MitraClip and the surgical repair groups had similar 30-day mortality rates (4 vs 13%, P = 0.41) and prevalence of serious adverse events (25 vs 38%, P = 0.43). The median follow-up was 1028 days (IQR: 272-1564 days) in the MitraClip group and 890 days (IQR: 436-1381 days) in the surgical group (P = 0.95). Total all-cause mortality (54 vs 60%, log-rank P = 0.64) and rates of rehospitalizations for heart failure (42 vs 29%, log-rank P = 0.68) did not differ significantly between groups. Both techniques were associated with significant decrease in NYHA class and severity of FMR (P < 0.001 for all) and with a similar degree of stabilization of LV remodelling (P = NS). Despite the significant baseline differences in accumulated expertise and risk profile between the surgical and the MitraClip groups, both minimally invasive techniques were associated with similar 30-day and long-term outcomes. |