Metal-organic frameworks as sorbents for pre-concentration of drugs and small peptides in MALDI TOF MS

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	KOLÁŘOVÁ Lenka PEČINKA Lukáš PEŇA MENDÉZ Eladia Maria CONDE Jose Elias HAVEL Josef
Rok publikování	2017
Druh	Další prezentace na konferencích
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Popis	Metal organic frameworks are highly porous and due to high surface area very promising materials for application as a sorbent. In this work various type of Metal organic frameworks (MOFs) as a tool for specific preconcentration of peptides and for small molecules as drugs were investigated. We found specific interaction of two peptides (angiotensin II and adrenocorticotropic hormone clip [1-17]) and we was able to pre-concentrated them 2 x and 120x using Basolite F300 and using Matrix-assisted laser desorption/ionization connecting with time of flight detection (TOF) mass spectroscopy (MS).