An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

Autoři	REKTOR Ivan BOHNEN N.I. KORCZYN A.D. GRYB V. KUMAR H. KRAMBERGER M.G. DE LEEUW F.E. PIRTOSEK Z. REKTOROVÁ Irena SCHLESINGER I. SLAWEK J. VALKOVIC P. VESELÝ Branislav
Rok publikování	2018
Druh	Článek v odborném periodiku
Časopis / Zdroj	PARKINSONISM & RELATED DISORDERS
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
www	https://www.sciencedirect.com/science/article/pii/S1353802017308696?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.parkreldis.2017.12.030
Klíčová slova	Binswanger's disease; Cerebrovascular disease; Gait; Vascular parkinsonism; Imaging
Popis	This expert working group report proposes an, updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity. The diagnosis of VaP is based on the presence of clinical parkinsonism, with variable motor and non motor signs that are corroborated by clinical, anatomic or imaging findings of cerebrovascular disease. Three VaP subtypes are presented: (1) The acute or subacute post-stroke VaP subtype presents with acute or subacute onset of parkinsonism, which is typically asymmetric and responds to dopaminergic drugs; (2) The more frequent insidious onset VaP subtype presents with progressive parkinsonism with prominent postural instability, gait impairment, corticospinal, cerebellar, pseudobulbar, cognitive and urinary symptoms and poor responsiveness to dopaminergic drugs. A higher-level gait disorder occurs frequently as a dominant manifestation in the clinical spectrum of insidious onset VaP, and (3) With the emergence of molecular imaging biomarkers in clinical practice, our diagnostic approach also allows the recognition of mixed or overlapping syndromes of VaP with Parkinson's disease or other neurodegenfor erative parkinsonisms. Directions for future research are also discussed. (C) 2018 Elsevier Ltd. All rights reserved.