Light-Activated Peptide-Based Materials for Sutureless Wound Closure

Autoři	MCTIERNAN CD CORTES DC LAZURKO C AMRANI S ROSALES-ROJAS R ZUNIGA-BUSTOS M SEDLÁKOVÁ Veronika POBLETE H STAMPLECOSKIE K SUURONEN EJ ALARCON EI
Rok publikování	2019
Druh	Článek v odborném periodiku
Časopis / Zdroj	ACS APPLIED MATERIALS & INTERFACES
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1021/acsami.9b18891
Klíčová slova	tissue photobonding; Rose Bengal; collagen; peptide; wound healing
Popis	Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.