Collagen-Based Microcapsules As Therapeutic Materials for Stem Cell Therapies in Infarcted Myocardium

Autoři	JACQUES E HOSOYAMA K BINIAM B CIMENCI CE SEDLÁKOVÁ Veronika STEEVES AJ VARIOLA F DAVIS DR STEWART DJ SUURONEN EJ ALARCON EI
Rok publikování	2020
Druh	Článek v odborném periodiku
Časopis / Zdroj	ACS BIOMATERIALS SCIENCE & ENGINEERING
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1021/acsbiomaterials.0c00245
Klíčová slova	cell encapsulation; tissue regeneration; biomimetic matrix; myocardial infarction
Popis	As cell therapies emerged, it was quickly realized that pro-regenerative cells directly injected into injured tissue struggled within the inflammatory microenvironment. By using microencapsulation, i.e., encapsulating cells within polymeric biomaterials, they are henceforth protected from the harmful extracellular cues, while still being able to receive oxygen and nutrients and release secreted factors. Previous work showed that stem cells encapsulated within a biologically inert material (agarose) were able to significantly improve the function of the infarcted mouse heart. With the aim of using more bioresponsive microcapsules, we sought to develop an enzymatically degradable, type I collagen-based microcapsule for the intramyocardial delivery of bone marrow-derived mesenchymal stromal cells in a murine model of myocardial infarction.