AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

Autoři	CALUORI Guido ODEHNALOVÁ Eva JADCZYK Tomasz PEŠL Martin PAVLOVÁ Iveta VALÍKOVÁ Lucia HOLZINGER Steffen NOVOTNÁ Veronika ROTREKL Vladimír HAMPL Aleš CRHA Michal ČERVINKA Dalibor STÁREK Zdeněk
Rok publikování	2020
Druh	Článek v odborném periodiku
Časopis / Zdroj	Frontiers in bioengineering and biotechnology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.frontiersin.org/articles/10.3389/fbioe.2020.552357/full
Doi	http://dx.doi.org/10.3389/fbioe.2020.552357
Klíčová slova	pulsed field ablation; irreversible electroporation (IRE); radiofrequency ablation; atrial fibrillation; ventricular arrhythmia (VA); preclinical cardiology
Popis	Pulsed field ablation (PFA) exploits the delivery of short high-voltage shocks to induce cells death via irreversible electroporation. The therapy offers a potential paradigm shift for catheter ablation of cardiac arrhythmia. We designed an AC-burst generator and therapeutic strategy, based on the existing knowledge between efficacy and safety among different pulses. We performed a proof-of-concept chronic animal trial to test the feasibility and safety of our method and technology.
Související projekty:	National research infrastructure for biological and medical imaging