Characteristics and Outcome of Patients with Acute Myeloid Leukemia and t(8;16)(p11;p13): Results from an International Collaboration

• Autoři: KAYSE Sabine; HILLS Robert K.; KRAMER Michael; NOVÁKOVÁ Zuzana; ESTEY Elihu H.; SHAW Carole; MAYER Jiří; ZAK Pavel; SZOTKOWSKI Tomas; CETKOVSKY Petr; GRIMWADE David; PLATZBECKER Uwe; KRÄMER Alwin; BURNETT Alan K.; HO Anthony D.; WALTER Roland B.; THIEDE Christian; EHNINGER Gerhard; RÖLLIG Christoph; MÜLLER-TIDOW Carsten; RUSSELL Nigel H.; SCHLENK Richard F.; MARK LEVIS
• Rok publikování: 2018
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Lékařská fakulta
• Popis: In adult patients (pts) with acute myeloid leukemia (AML), the balanced translocation t(8;16)(p11;p13) is a very rare abnormality resulting in the fusion of MYST3 and CREBBP. Both genes encode proteins with histone acetyltransferase activity and are involved in transcriptional regulation. Previous small series suggested a poor outcome but neither prospective nor larger retrospective cohort studies are available to support these results.