The Evolution of Chromosome Numbers: Mechanistic Models and Experimental Approaches

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Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

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MAYROSE I. LYSÁK Martin

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj GENOME BIOLOGY AND EVOLUTION
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://academic.oup.com/gbe/article/13/2/evaa220/5923296#227709395
Doi http://dx.doi.org/10.1093/gbe/evaa220
Klíčová slova chromosome numbers; polyploidy; dysploidy; cytogenomics; phylogenetic models; genome evolution
Popis Chromosome numbers have been widely used to describe the most fundamental genomic attribute of an organism or a lineage. Although providing strong phylogenetic signal, chromosome numbers vary remarkably among eukaryotes at all levels of taxonomic resolution. Changes in chromosome numbers regularly serve as indication of major genomic events, most notably polyploidy and dysploidy. Here, we review recent advancements in our ability to make inferences regarding historical events that led to alterations in the number of chromosomes of a lineage. We first describe the mechanistic processes underlying changes in chromosome numbers, focusing on structural chromosomal rearrangements. Then, we focus on experimental procedures, encompassing comparative cytogenomics and genomics approaches, and on computational methodologies that are based on explicit models of chromosome-number evolution. Together, these tools offer valuable predictions regarding historical events that have changed chromosome numbers and genome structures, as well as their phylogenetic and temporal placements.
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