Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Autoři

ANKER SD BUTLER J FILIPPATOS G FERREIRA JP BOCCHI E BOHM M BRUNNER-LA Rocca HP CHOI DJ CHOPRA V CHUQUIURE-VALENZUELA E GIANNETTI N GOMEZ-MESA JE JANSSENS S JANUZZI JL GONZALEZ-JUANATEY JR MERKELY B NICHOLLS SJ PERRONE SV PINA IL PONIKOWSKI P SENNI M SIM D ŠPINAR Jindřich SQUIRE I TADDEI S TSUTSUI H VERMA S VINEREANU D ZHANG J CARSON P LAM CSP MARX N ZELLER C SATTAR N JAMAL W SCHNAIDT S SCHNEE JM BRUECKMANN M POCOCK SJ ZANNAD F PACKER M

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj New England Journal of Medicine
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.nejm.org/doi/10.1056/NEJMoa2107038
Doi http://dx.doi.org/10.1056/NEJMoa2107038
Klíčová slova Heart Failure; Empagliflozin; Preserved Ejection Fraction
Popis BACKGROUND Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. METHODS In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. RESULTS Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P<0.001). This effect was mainly related to a lower risk of hospitalization for heart failure in the empagliflozin group. The effects of empagliflozin appeared consistent in patients with or without diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (407 with empagliflozin and 541 with placebo; hazard ratio, 0.73; 95% CI, 0.61 to 0.88; P<0.001). Uncomplicated genital and urinary tract infections and hypotension were reported more frequently with empagliflozin. CONCLUSIONS Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info