Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Farmaceutickou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři

MARIKOVA J. AL MAMUN A. AL SHAMMARI L. KORABECNY J. KUCERA T. HULCOVA D. KUNES J. MALANÍK Milan VASKOVA M. KOHELOVA E. NOVAKOVA L. CAHLIKOVA L. POUR M.

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Molecules
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
www https://www.mdpi.com/1420-3049/26/5/1279
Doi http://dx.doi.org/10.3390/molecules26051279
Klíčová slova Amaryllidaceae; 9-O-demethyllycorenine; narciabduliine; Alzheimer’ s disease
Popis Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum x hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 +/- 0.73 mu M for hAChE and 3.44 +/- 0.02 mu M for hBuChE. The accommodation of 2 into the active sites of respective enzymes was predicted using molecular modeling simulation.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info