Medical algorithm: Diagnosis and management of antibody immunodeficiencies


SEDIVA Anna MILOTA Tomas LITZMAN Jiří QUINTI Isabella MEYTS Isabelle BURNS Siobhan JOLLES Stephen

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Allergy
Fakulta / Pracoviště MU

Lékařská fakulta

Klíčová slova b cells; clinical immunology; immune deficiencies
Přiložené soubory
Popis Primary antibody deficiencies (PAD) constitute the majority of all primary immunodeficiency diseases (PID) also termed inborn errors of immunity (IEI). This category (PAD) represents around 52% of all IEI and the proportion overall is still greater given that antibody deficiency is a component of other groups including combined and severe combined immunodeficiencies (SCID), autoinflammatory disorders, diseases of immune dysregulation and other well-defined PIDs.1 Secondary antibody deficiencies (SAD) represent a larger and expanding number of individuals resulting from the use of a wide range of immunosuppressive therapies, in particular those targeting B cells, and may also result from renal or gastrointestinal immunoglobulin losses, infections, for example, HIV or malaria, malnutrition or others.

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