Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies

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Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

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LAMOŠ Martin MORÁVKOVÁ Ivona ONDRÁČEK David BOČKOVÁ Martina REKTOROVÁ Irena

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Movement Disorders
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28741
Doi http://dx.doi.org/10.1002/mds.28741
Klíčová slova EEG microstates; synucleinopathy; medication-naive; MCI-LB; prodromal DLB
Popis Background Electrophysiological markers of prodromal dementia with Lewy bodies were described in the spectral domain. The sub-second temporal resolution may provide additional information. Objective To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies and to assess the association between their temporal dynamics and the spectral marker. Methods Temporal parameters of microstates were compared between 21 patients with mild cognitive impairment with Lewy bodies and 21 healthy controls. The dominant alpha frequency was correlated with microstate parameters. Results Microstates A-D showed higher occurrence in the patient group. Microstate B additionally revealed shorter mean duration and increased time coverage; its occurrence correlated with the dominant alpha frequency in the patient group. Conclusions Temporal dynamics of all EEG microstates were altered in medication-naive subjects with prodromal dementia with Lewy bodies. Longitudinal follow-up may reveal how EEG microstates reflect progression of brain function deficits and effects of treatment manipulations. (c) 2021 International Parkinson and Movement Disorder Society
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