Memory retrieval in temporal lobe epilepsy is related to functional segregation of the mesiotemporal structures

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Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

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STRÝČEK Ondřej LAMOŠ Martin REKTOR Ivan

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj EPILEPSY & BEHAVIOR
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.sciencedirect.com/science/article/pii/S1525505021004571?via%3Dihub
Doi http://dx.doi.org/10.1016/j.yebeh.2021.108196
Klíčová slova Temporal lobe epilepsy; High-density EEG; Functional connectivity; Memory network
Popis Objective: We analyzed the impact of temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) on functional connectivity (FC) between mesiotemporal structures. Functional connectivity modifications related to word retrieval were investigated. Methods: High-density EEG of 21 patients with TLE with HS (12 left TLE and 9 right TLE) and 10 healthy controls (HCs) were recorded during a verbal subsequent memory paradigm. Electroencephalography data were reconstructed into the source space and FC was calculated from the source activity of regions of interest. Results: A significant decrease in FC between the right-and left-sided mesiotemporal structures in TLE was observed. The decrease was significant only with words that were correctly recognized. The decrease in interhemispheric FC between mesiotemporal structures was found in the 8-to 20-Hz frequency range in both left and right TLE. Significance: The decreased FC between the mesiotemporal structures in TLE is a condition for successful performance of a memory retrieval task. The successful memory retrieval in TLE is related to functional segregation of lesional from nonlesional mesiotemporal structures. This decrease was absent in non successful responses. (c) 2021 Elsevier Inc. All rights reserved.
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