Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	KOCURKOVÁ Anna NESPOROVA Kristina SANDANUSOVÁ Miriam KERBEROVÁ Michaela LEHKÁ Kateřina VELEBNÝ Vladimír KUBALA Lukáš AMBROŽOVÁ Gabriela
Rok publikování	2022
Druh	Článek v odborném periodiku
Časopis / Zdroj	Biomolecules
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
www	https://www.mdpi.com/2218-273X/12/1/45
Doi	http://dx.doi.org/10.3390/biom12010045
Klíčová slova	peritoneal adhesion; fibrosis; hyaluronan; mesothelial cell; metabolism; inflammation; mesothelial-to-mesenchymal transition
Popis	Formation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-fibrotic phenotype. Pro-fibrotic transition of MCs-mesothelial-to-mesenchymal transition (MMT), and fibroblasts activation to myofibroblasts are interconnected to changes in cellular metabolism and culminate in the deposition of extracellular matrix (ECM) in the form of fibrotic tissue between injured sides in the abdominal cavity. However, ECM is not only a mechanical scaffold of the newly synthetized tissue but reciprocally affects fibrosis development. Hyaluronan (HA), an important component of ECM, is a non-sulfated glycosaminoglycan consisting of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcUA) that can affect the majority of processes involved in PA formation. This review considers the role of endogenously produced HA in the context of different fibrosis-related pathologies and its overlap in the development of PA.