A Systematic Review of Cost-effectiveness Analyses of Durvalumab Consolidation Therapy Versus no Consolidation Therapy After Chemoradiotherapy in Stage-III NSCLC


HUSSAIN Mohammad Salman KLUGAROVÁ Jitka KLUGAR Miloslav

Rok publikování 2022
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Popis Background Recently, Durvalumab was approved as a potential immunotherapy for the management of unresectable stage III NSCLC. To date, economic studies from different parts of the world presented varying findings. Objective So, the objective of this study was to assess the cost-effectiveness of durvalumab consolidation therapy versus no consolidation therapy in patients with unresectable stage III NSCLC. Methods PubMed, Embase, and Cochrane Central databases were searched till March 2022 to identify all the studies assessing the economic evaluation of durvalumab in patients with unresectable stage III NSCLC. Eligible studies were screened by two reviewers independently and the quality of included studies was evaluated using the updated version of CHEERS 2022 checklists. Incremental cost-effectiveness ratio (ICER) data were converted to 2022 US dollars ($). Results A total of seven studies were found to be eligible for inclusion. The healthcare payers’ perspective was the most common study perspective among the included studies. Four included studies used the Markov model. The ICER of durvalumab consolidation therapy after unresectable stage III NSCLC in the US was found to be in the range of $59,850 to $145,543 per Quality-Adjusted Life Years (QALY). Likewise, the ICER of durvalumab in European countries was found to be in the range of $62,021 to $76,068 per QALY. Durvalumab was found to be cost-effective among all the included studies as the ICER was below the implemented country-specific willingness-to-pay thresholds. Conclusion Durvalumab consolidation therapy was found to be cost-effective versus no consolidation therapy after chemoradiotherapy in stage-III NSCLC patients.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info