SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Autoři	DE LUCA Giuseppe ALGOWHARY Magdy UGUZ Berat OLIVEIRA Dinaldo C GANYUKOV Vladimir ZIMBAKOV Zan CERCEK Miha JENSEN Lisette Okkels LOH Poay Huan CALMAC Lucian FERRER Gerard Roura I QUADROS Alexandre MILEWSKI Marek SCOTTO Di Uccio Fortunato CLEMENS von Birgelen VERSACI Francesco JURRIEN Ten Berg CASELLA Gianni LUNG Aaron Wong Sung KALA Petr GIL Jose Luis Diez CARRILLO Xavier DIRKSEN Maurits BECERRA-MUNOZ Victor M LEE Michael Kang-Yin JUZAR Dafsah Arifa JOAQUIM Rodrigo de Moura CIRO De Simone MILICIC Davor DAVLOUROS Periklis BAKRACESKI Nikola ZILIO Filippo DONAZZAN Luca KRAAIJEVELD Adriaan GALASSO Gennaro ARPAD Lux MARINUCCI Lucia GUIDUCCI Vincenzo MENICHELLI Maurizio SCOCCIA Alessandra YAMAC Aylin Hatice MERT Kadir Ugur RIOS Xacobe Flores KOVARNIK Tomas KIDAWA Michal MOREU Jose FLAVIEN Vincent FABRIS Enrico MARTINEZ-LUENGAS Inigo Lozano BOCCALATTE Marco OJEDA Francisco Bosa ARELLANO-SERRANO Carlos CAIAZZO Gianluca CIRRINCIONE Giuseppe KAO Hsien-Li FORES Juan Sanchis VIGNALI Luigi PEREIRA Helder MANZO-SILBERMANN Stephane ORDONEZ Santiago OZKAN Alev Arat SCHELLER Bruno LEHTOLA Heidi TELES Rui MANTIS Christos ANTTI Ylitalo SILVEIRA Joao Antonio Brum BESSONOV Ivan ZONI Rodrigo SAVONITTO Stefano KOCHIADAKIS George ALEXOPOULOS Dimitrios URIBE Carlos E KANAKAKIS John FAURIE Benjamin GABRIELLI Gabriele BARRIOS Alejandro Gutierrez BACHINI Juan Pablo ROCHA Alex TAM Frankie Chor-Cheung RODRIGUEZ Alfredo LUKITO Antonia Anna BELLEMAIN-APPAIX Anne PESSAH Gustavo CORTESE Giuliana PARODI Guido BURGADHA Mohammed Abed KEDHI Elvin LAMELAS Pablo SURYAPRANATA Harry NARDIN Matteo VERDOIA Monica
Rok publikování	2023
Druh	Článek v odborném periodiku
Časopis / Zdroj	ANGIOLOGY
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://journals.sagepub.com/doi/10.1177/00033197221129351
Doi	http://dx.doi.org/10.1177/00033197221129351
Klíčová slova	thrombosis; STEMI; outcome
Popis	SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P = .002), less often active smokers (P = .002), and hypercholesterolemic (P = .006), they presented more often later than 12 h (P = .037), more often to the hub and were more often in cardiogenic shock (P = .02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P < .0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P = .029) and more thrombectomy (P = .046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P < .001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P < .001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P < .001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences.