Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology

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AĆIMOVIĆ Ivana GABRIELOVÁ Viktorie MARTÍNKOVÁ Stanislava EID Michal VLAŽNÝ Jakub MORAVČÍK Petr HLAVSA Jan MORÁŇ Lukáš CAKMAKCI Riza Can STAŇO Peter PROCHÁZKA Vladimír KALA Zdeněk TRNKA Jan VAŇHARA Petr

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj PANCREAS
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://journals.lww.com/pancreasjournal/abstract/9900/ex_vivo_3d_cellular_models_of_pancreatic_ductal.188.aspx
Doi http://dx.doi.org/10.1097/MPA.0000000000002393
Popis Pancreas is a vital gland of gastro-intestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a five-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, the identification of novel molecular targets, and the development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing three-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.
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