Pretreatment with alpha-methyl-5-hydroxytryptamine attenuates methamphetamine i.v. self-administration in rats
| Autoři | |
|---|---|
| Rok publikování | 2003 |
| Druh | Článek ve sborníku |
| Konference | PROGRAMME AND ABSTRACTS of 5th NEUROCHEMISTRY WINTER CONFERENCE |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | 5-HT2 receptor subtype; methamphetamine; "i.v. self-administration"; rats |
| Popis | To ascertain the involvement of 5-HT2 receptor subtype in rewarding properties of methamphetamine (METH), non-selective 5-HT2 agonist alpha-methyl-5-hydroxytryptamine was tested for its ability to influence METH "i.v. self-administration" in rats. From our results, 5-HT2 receptor activation slightly attenuated METH self-administration. This ability can be hypothetically mediated via supression of either "craving" or sensitization mechanisms. |
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